Research workbench
Crystal structure of fibroblast growth factor (FGF)8B in complex with FGF receptor (fgfr) 2C
Analyse Crystal structure of fibroblast growth factor (FGF)8B in complex with FGF… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2FDB
- Type
- protein
- Length
- 685 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor 8 isoform B; Fibroblast growth factor receptor 2
- EC
- 2.7.1.112
- UniProt
- P55075, Q9UQH9
- Pockets
- 6 · best druggability 0.65
Structure
x-ray diffraction · 4 distinct chains · 10% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| M | Fibroblast growth factor 8 isoform B | protein | 149 | 13% helix, 38% strand | P55075 |
| P | Fibroblast growth factor receptor 2 (EC 2.7.1.112) | protein | 197 | 8% helix, 55% strand | Q9UQH9 |
| N | Fibroblast growth factor 8 isoform B | protein | 148 | 13% helix, 38% strand | P55075 |
| R | Fibroblast growth factor receptor 2 (EC 2.7.1.112) | protein | 191 | 8% helix, 52% strand | Q9UQH9 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 603 | 0.65 | 0.76 | 63 | empty |
| 2 | 516 | 0.61 | 0.75 | 55 | empty |
| 3 | 234 | 0.55 | 0.78 | 28 | empty |
| 4 | 103 | 0.38 | 0.75 | 18 | empty |
| 5 | 76 | 0.33 | 0.75 | 13 | empty |
Interfaces
5 interfaces between chains.
- M–P · 1810 Ų buried · 31 hydrogen bonds · protein-protein
- N–R · 1689 Ų buried · 28 hydrogen bonds · protein-protein
- P–R · 988 Ų buried · 14 hydrogen bonds · protein-protein
- M–R · 152 Ų buried · 0 hydrogen bonds · protein-protein
- P–N · 147 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2FDB · Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR)… · the same entry in another collection · chain M against M, TM-score 1.00
- P55075 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 8 (P55075) · a predicted model of the same protein · chain M against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55075
- Every structure of UniProt Q9UQH9
- Elsewhere: RCSB PDB 2FDB · PDBe 2FDB · UniProt P55075 · UniProt Q9UQH9
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