MolNFT v1 · #36589 · protein
The crystal structure of SAR1[H79G]-GDP provides insight into the coat-controlled GTP hydrolysis in the disassembly of cop II
2FA9 · GTP-binding protein SAR1B: “The crystal structure of SAR1[H79G]-GDP provides insight into the coat-controlled GTP hydrolysis in the…”. X-ray diffraction, 3 ligands (GDP, MG, SO4), 3 pockets (best druggability 0.48). MolNFT v1 #36589…
- PDB
- 2FA9
- Type
- protein
- Length
- 347 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTP-binding protein SAR1B
- UniProt
- Q9QVY3
- Ligands
- GDP, MG, SO4
- Pockets
- 3 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GTP-binding protein SAR1B | protein | 169 | 31% helix, 23% strand | Q9QVY3 |
| B | GTP-binding protein SAR1B | protein | 178 | 31% helix, 21% strand | Q9QVY3 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 209 | 0.48 | 0.75 | 43 | GDP |
| 2 | 81 | 0.41 | 0.78 | 16 | empty |
| 3 | 50 | 0.25 | 0.74 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 537 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 2FA9 · The crystal structure of Sar1[H79G]-GDP provides insight into the coat-controlled GTP… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9QVY3 · AlphaFold monomer V2.0 prediction for GTP-binding protein SAR1B (Q9QVY3) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9QVY3
- Elsewhere: RCSB PDB 2FA9 · PDBe 2FA9 · UniProt Q9QVY3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.