MolNFT v1 · #36545 · protein
Crystal structure of human NOTCH1 ankyrin repeats to 1.55A resolution.
2F8Y · Notch homolog 1, translocation-associated (drosophila): “Crystal structure of human NOTCH1 ankyrin repeats to 1.55A resolution.”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.65). MolNFT v1 #36545 on GenesisL1…
- PDB
- 2F8Y
- Type
- protein
- Length
- 424 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Notch homolog 1, translocation-associated (drosophila)
- UniProt
- P46531
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 47% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Notch homolog 1, translocation-associated (drosophila) | protein | 215 | 46% helix, 3% strand | P46531 |
| B | Notch homolog 1, translocation-associated (drosophila) | protein | 209 | 49% helix, 0% strand | P46531 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 153 | 0.65 | 0.87 | 16 | empty |
| 2 | 78 | 0.33 | 0.75 | 15 | empty |
| 3 | 59 | 0.27 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 506 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 2F8Y · Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution. · the same entry in another collection · chain A against A, TM-score 1.00
- P46531 · AlphaFold monomer V2.0 prediction for neurogenic locus notch homolog protein 1 (P46531) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46531
- Elsewhere: RCSB PDB 2F8Y · PDBe 2F8Y · UniProt P46531
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.