MolNFT v1 · #36542 · protein

Structure of full length telethonin in complex with the N-terminus of titin

2F8V · N2B-titin isoform: “Structure of full length telethonin in complex with the N-terminus of titin”. X-ray diffraction, 1 ligand (SO4), 8 pockets (best druggability 0.79). MolNFT v1 #36542 on GenesisL1: 3D structure, binding sites and…

PDB: 2F8V
Type: protein
Length: 951 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: N2B-titin isoform; Telethonin
UniProt: Q8WZ42, O15273
Ligands: SO4
Pockets: 8 · best druggability 0.79

Structure

x-ray diffraction · 5 distinct chains · 3% helix, 63% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	N2B-titin isoform	protein	194	3% helix, 63% strand	Q8WZ42
B	N2B-titin isoform	protein	197	3% helix, 63% strand	Q8WZ42
T, Y	Telethonin	protein	88	0% helix, 69% strand	O15273
C	N2B-titin isoform	protein	191	3% helix, 61% strand	Q8WZ42
D	N2B-titin isoform	protein	193	3% helix, 61% strand	Q8WZ42

Ligands and binding sites

SO4 · Sulfate ion · ion · 5 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1112	0.79	0.80	89	empty
2	410	0.68	0.80	38	empty
3	513	0.63	0.76	54	SO4
4	186	0.57	0.80	28	empty
5	149	0.51	0.79	26	empty

Interfaces

8 interfaces between chains.

D–Y · 1932 Å² buried · 46 hydrogen bonds · protein-protein
B–T · 1921 Å² buried · 43 hydrogen bonds · protein-protein
A–T · 1626 Å² buried · 37 hydrogen bonds · protein-protein
C–Y · 1618 Å² buried · 32 hydrogen bonds · protein-protein
A–D · 458 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

2F8V · Structure of full length telethonin in complex with the N-terminus of titin · the same entry in another collection · chain A against A, TM-score 1.00
O15273 · AlphaFold monomer V2.0 prediction for telethonin (O15273) · a predicted model of the same protein · chain T against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8WZ42
Every structure of UniProt O15273
Elsewhere: RCSB PDB 2F8V · PDBe 2F8V · UniProt Q8WZ42 · UniProt O15273

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