MolNFT v1 · #36452 · protein

Solution structure of hppk in complex with inhibitor analogs ampcpp and hp-1

2F63 · 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine…: “Solution structure of hppk in complex with inhibitor analogs ampcpp and hp-1”. Solution nmr, 1 pocket (best druggability 0.56). MolNFT v1 #36452 on GenesisL1: 3D structure…

PDB: 2F63
Type: protein
Length: 158 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EC: 2.7.6.3
UniProt: P26281
Pockets: 1 · best druggability 0.56

Structure

solution nmr · 1 distinct chain · 26% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3)	protein	158	26% helix, 22% strand	P26281

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	196	0.56	0.80	28	empty

Compared structures

2F63 · Solution structure of HPPK in complex with inhibitor analogs AMPCPP and HP-1 · the same entry in another collection · chain A against A, TM-score 1.00
P26281 · AlphaFold monomer V2.0 prediction for 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine… · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P26281
Elsewhere: RCSB PDB 2F63 · PDBe 2F63 · UniProt P26281

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