MolNFT v1 · #36414 · protein
Barnase cross-linked with glutaraldehyde
2F4Y · Ribonuclease: “Barnase cross-linked with glutaraldehyde”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.64). MolNFT v1 #36414 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2F4Y
- Type
- protein
- Length
- 324 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribonuclease
- EC
- 3.1.27.-
- UniProt
- P00648
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 22% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Ribonuclease (EC 3.1.27.-) | protein | 108 | 22% helix, 23% strand | P00648 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 420 | 0.64 | 0.78 | 35 | empty |
Interfaces
3 interfaces between chains.
- B–C · 200 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 122 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 24 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2F4Y · Barnase cross-linked with glutaraldehyde · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00648
- Elsewhere: RCSB PDB 2F4Y · PDBe 2F4Y · UniProt P00648
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