MolNFT v1 · #36391 · protein

Xray crystal structure of T4 lysozyme mutant L20/R63A liganded to methylguanidinium

2F47: “Xray crystal structure of T4 lysozyme mutant L20/R63A liganded to methylguanidinium”. X-ray diffraction, 2 ligands (MGX, CL), 1 pocket (best druggability 0.51). MolNFT v1 #36391 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 2F47
Type: protein
Length: 175 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lysozyme
EC: 3.2.1.17
UniProt: P00720
Ligands: MGX, CL
Pockets: 1 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 64% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lysozyme (EC 3.2.1.17)	protein	175	64% helix, 10% strand	P00720

Ligands and binding sites

MGX · 1-methylguanidine · ligand · chains A
CL · Chloride ion · ion · chains A
BME · Beta-mercaptoethanol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	236	0.51	0.75	28	empty

Compared structures

2F47 · Xray crystal structure of T4 lysozyme mutant L20/R63A liganded to methylguanidinium · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00720
Elsewhere: RCSB PDB 2F47 · PDBe 2F47 · UniProt P00720

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