MolNFT v1 · #36383 · protein
CALMODULIN/IQ domain complex
2F3Y: “CALMODULIN/IQ domain complex”. X-ray diffraction, 2 ligands (CA, MG), 2 pockets (best druggability 0.47). MolNFT v1 #36383 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2F3Y
- Type
- protein
- Length
- 164 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin; Voltage-dependent L-type calcium channel alpha-1C subunit
- UniProt
- P62158, Q13933
- Ligands
- CA, MG
- Pockets
- 2 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 63% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calmodulin | protein | 146 | 60% helix, 5% strand | P62158 |
| B | Voltage-dependent L-type calcium channel alpha-1C subunit | protein | 18 | 83% helix, 0% strand | Q13933 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 167 | 0.47 | 0.76 | 24 | empty |
| 2 | 62 | 0.34 | 0.77 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1260 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2F3Y · Calmodulin/IQ domain complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62158
- Every structure of UniProt Q13933
- Elsewhere: RCSB PDB 2F3Y · PDBe 2F3Y · UniProt P62158 · UniProt Q13933
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