MolNFT v1 · #36343 · protein
Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode
2F2P · Calmodulin fused with calmodulin-binding domain of…: “Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode”. X-ray diffraction, 1 ligand (CA), 2 pockets (best druggability 0.57). MolNFT v1…
- PDB
- 2F2P
- Type
- protein
- Length
- 338 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin fused with calmodulin-binding domain of calcineurin
- UniProt
- P62157, Q309F2
- Ligands
- CA
- Pockets
- 2 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 63% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Calmodulin fused with calmodulin-binding domain of calcineurin | protein | 169 | 63% helix, 2% strand | P62157, Q309F2 |
Ligands and binding sites
- CA · Calcium ion · metal · 8 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 340 | 0.57 | 0.76 | 52 | empty |
| 2 | 93 | 0.47 | 0.80 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1874 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 2F2P · Structure of calmodulin bound to a calcineurin peptide: a new way of making an old… · the same entry in another collection · chain A against A, TM-score 1.00
- P62157 · AlphaFold monomer V2.0 prediction for calmodulin (P62157) · a predicted model of the same protein · chain B against A, TM-score 0.57
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62157
- Every structure of UniProt Q309F2
- Elsewhere: RCSB PDB 2F2P · PDBe 2F2P · UniProt P62157 · UniProt Q309F2
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