MolNFT v1 · #36146 · protein
Ecoli biotin repressor with co-repressor analog
2EWN · Bira bifunctional protein: “Ecoli biotin repressor with co-repressor analog”. X-ray diffraction, 1 ligand (BTX), 8 pockets (best druggability 0.73). MolNFT v1 #36146 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2EWN
- Type
- protein
- Length
- 635 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bira bifunctional protein
- EC
- 6.3.4.15
- UniProt
- P06709
- Ligands
- BTX
- Pockets
- 8 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bira bifunctional protein (EC 6.3.4.15) | protein | 318 | 30% helix, 29% strand | P06709 |
| B | Bira bifunctional protein (EC 6.3.4.15) | protein | 317 | 32% helix, 28% strand | P06709 |
Ligands and binding sites
- BTX · ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methyl 5-((3as,4s,6ar)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentyl hydrogen phosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 157 | 0.73 | 0.92 | 35 | BTX |
| 2 | 576 | 0.72 | 0.80 | 58 | empty |
| 3 | 308 | 0.69 | 0.83 | 45 | BTX |
| 4 | 228 | 0.68 | 0.85 | 39 | empty |
| 5 | 200 | 0.65 | 0.85 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 1288 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06709
- Elsewhere: RCSB PDB 2EWN · PDBe 2EWN · UniProt P06709
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.