MolNFT v1 · #35996 · protein

Structure of the regulator of G-protein signaling domain of RGS6

2ES0 · Regulator of G-protein signalling 6: “Structure of the regulator of G-protein signaling domain of RGS6”. X-ray diffraction, 1 pocket (best druggability 0.34). MolNFT v1 #35996 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 2ES0
Type: protein
Length: 129 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Regulator of G-protein signalling 6
UniProt: P49758
Pockets: 1 · best druggability 0.34

Structure

x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Regulator of G-protein signalling 6	protein	129	73% helix, 0% strand	P49758

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	54	0.34	0.77	11	empty

Compared structures

2ES0 · Structure of the regulator of G-protein signaling domain of RGS6 · the same entry in another collection · chain A against A, TM-score 1.00
P49758 · AlphaFold monomer V2.0 prediction for regulator of G-protein signaling 6 (P49758) · a predicted model of the same protein · chain A against A, TM-score 0.71

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P49758
Elsewhere: RCSB PDB 2ES0 · PDBe 2ES0 · UniProt P49758

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