MolNFT v1 · #3568 · protein

Human P56LCK tyrosine kinase complexed with phosphopeptide

1CWD: “Human P56LCK tyrosine kinase complexed with phosphopeptide”. X-ray diffraction. MolNFT v1 #3568 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1CWD
Type: protein
Length: 106 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: P56LCK tyrosine kinase; (PHOSPHONOMETHYL)PHENYLALANINE-containing peptide pro-glu…
UniProt: P06239

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	P56LCK tyrosine kinase	protein	98	18% helix, 36% strand	P06239
P	(PHOSPHONOMETHYL)PHENYLALANINE-containing peptide pro-glu- gly-asp-PM3-glu-glu-val-leu	protein	8	0% helix, 0% strand	—

Interfaces

1 interface between chains.

L–P · 420 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (nonstandard).

Compared structures

1CWD · Human P56LCK tyrosine kinase complexed with phosphopeptide · the same entry in another collection · chain L against L, TM-score 1.00
P06239 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase lck (P06239) · a predicted model of the same protein · chain L against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06239
Elsewhere: RCSB PDB 1CWD · PDBe 1CWD · UniProt P06239

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