MolNFT v1 · #35639 · protein
The structure of the C-terminal domain of the protein kinase ATSOS2 bound to the calcium sensor ATSOS3
2EHB · Calcineurin B-like protein 4: “The structure of the C-terminal domain of the protein kinase ATSOS2 bound to the calcium sensor ATSOS3”. X-ray diffraction, 1 ligand (CA), 2 pockets (best druggability 0.65). MolNFT v1 #35639 on…
- PDB
- 2EHB
- Type
- protein
- Length
- 308 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcineurin B-like protein 4; Cbl-interacting SERINE/THREONINE-protein kinase 24
- EC
- 2.7.11.1
- UniProt
- O81223, Q9LDI3
- Ligands
- CA
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calcineurin B-like protein 4 | protein | 182 | 60% helix, 4% strand | O81223 |
| D | Cbl-interacting SERINE/THREONINE-protein kinase 24 (EC 2.7.11.1) | protein | 126 | 33% helix, 30% strand | Q9LDI3 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 501 | 0.65 | 0.77 | 43 | empty |
| 2 | 52 | 0.25 | 0.73 | 13 | empty |
Interfaces
1 interface between chains.
- A–D · 1946 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 2EHB · The structure of the C-terminal domain of the protein kinase AtSOS2 bound to the calcium… · the same entry in another collection · chain A against A, TM-score 1.00
- O81223 · AlphaFold monomer V2.0 prediction for calcineurin B-like protein 4 (O81223) · a predicted model of the same protein · chain A against A, TM-score 0.96
- Q9LDI3 · AlphaFold monomer V2.0 prediction for cbl-interacting SERINE/THREONINE-protein kinase 24… · a predicted model of the same protein · chain D against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O81223
- Every structure of UniProt Q9LDI3
- Elsewhere: RCSB PDB 2EHB · PDBe 2EHB · UniProt O81223 · UniProt Q9LDI3
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