MolNFT v1 · #35616 · protein

Crystal structure of tamalin PDZ domain in complex with MGLUR5 C- terminal peptide

2EGN · General receptor for phosphoinositides 1-associated…: “Crystal structure of tamalin PDZ domain in complex with MGLUR5 C- terminal peptide”. X-ray diffraction, 1 pocket (best druggability 0.36). MolNFT v1 #35616 on GenesisL1: 3D…

PDB: 2EGN
Type: protein
Length: 88 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: General receptor for phosphoinositides 1-associated scaffold protein; MGLUR5 C-terminal…
UniProt: Q8R4T5
Pockets: 1 · best druggability 0.36

Structure

x-ray diffraction · 2 distinct chains · 16% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	General receptor for phosphoinositides 1-associated scaffold protein	protein	83	17% helix, 39% strand	Q8R4T5
B	MGLUR5 C-terminal peptide	protein	5	0% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	82	0.36	0.76	13	empty

Interfaces

1 interface between chains.

A–B · 109 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

2EGN · Crystal Structure of Tamalin PDZ Domain in Complex with mGluR5 C-terminal Peptide · the same entry in another collection · chain A against A, TM-score 1.00
Q8R4T5 · AlphaFold monomer V2.0 prediction for general receptor for phosphoinositides 1-associated… · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8R4T5
Elsewhere: RCSB PDB 2EGN · PDBe 2EGN · UniProt Q8R4T5

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