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Crystal structure of tamalin PDZ domain in complex with MGLUR5 C- terminal peptide
Analyse Crystal structure of tamalin PDZ domain in complex with MGLUR5 C- terminal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2EGN
- Type
- protein
- Length
- 88 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- General receptor for phosphoinositides 1-associated scaffold protein; MGLUR5 C-terminal…
- UniProt
- Q8R4T5
- Pockets
- 1 · best druggability 0.36
Structure
x-ray diffraction · 2 distinct chains · 16% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | General receptor for phosphoinositides 1-associated scaffold protein | protein | 83 | 17% helix, 39% strand | Q8R4T5 |
| B | MGLUR5 C-terminal peptide | protein | 5 | 0% helix, 0% strand | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 82 | 0.36 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 109 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 2EGN · Crystal Structure of Tamalin PDZ Domain in Complex with mGluR5 C-terminal Peptide · the same entry in another collection · chain A against A, TM-score 1.00
- Q8R4T5 · AlphaFold monomer V2.0 prediction for general receptor for phosphoinositides 1-associated… · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8R4T5
- Elsewhere: RCSB PDB 2EGN · PDBe 2EGN · UniProt Q8R4T5
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