MolNFT v1 · #35464 · protein
Crystal structure of the exctracellular domain of the receptor tyrosine kinase, kit
2EC8 · MAST/STEM cell growth factor receptor: “Crystal structure of the exctracellular domain of the receptor tyrosine kinase, kit”. X-ray diffraction, 1 ligand (NAG), 3 pockets (best druggability 0.47). MolNFT v1 #35464 on GenesisL1: 3D…
- PDB
- 2EC8
- Type
- protein
- Length
- 464 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MAST/STEM cell growth factor receptor
- EC
- 2.7.10.1
- UniProt
- P10721
- Ligands
- NAG
- Pockets
- 3 · best druggability 0.47
Structure
x-ray diffraction · 1 distinct chain · 1% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MAST/STEM cell growth factor receptor (EC 2.7.10.1) | protein | 464 | 1% helix, 47% strand | P10721 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 5 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 156 | 0.47 | 0.76 | 19 | empty |
| 2 | 74 | 0.39 | 0.78 | 19 | empty |
| 3 | 72 | 0.30 | 0.73 | 14 | empty |
Modifications
Observed in the structure: 5 disulfide, 5 glycan (disulfide, N-glycosylation).
Compared structures
- 2EC8 · Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit · the same entry in another collection · chain A against A, TM-score 1.00
- P10721 · AlphaFold monomer V2.0 prediction for MAST/STEM cell growth factor receptor kit (P10721) · a predicted model of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10721
- Elsewhere: RCSB PDB 2EC8 · PDBe 2EC8 · UniProt P10721
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