MolNFT v1 · #35345 · protein

Solution structure of dynein light chain 2A

2E8J · Dynein light chain 2A, cytoplasmic: “Solution structure of dynein light chain 2A”. Solution nmr, 3 pockets (best druggability 0.63). MolNFT v1 #35345 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2E8J
Type: protein
Length: 192 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dynein light chain 2A, cytoplasmic
UniProt: Q9NP97
Pockets: 3 · best druggability 0.63

Structure

solution nmr · 1 distinct chain · 35% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Dynein light chain 2A, cytoplasmic	protein	96	35% helix, 31% strand	Q9NP97

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	105	0.63	0.88	18	empty
2	130	0.61	0.85	16	empty
3	307	0.53	0.74	40	empty

Interfaces

1 interface between chains.

A–B · 1045 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

2E8J · Solution structure of dynein light chain 2A · the same entry in another collection · chain A against A, TM-score 1.00
Q9NP97 · AlphaFold monomer V2.0 prediction for dynein light chain roadblock- type 1 (Q9NP97) · a predicted model of the same protein · chain B against A, TM-score 0.83

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NP97
Elsewhere: RCSB PDB 2E8J · PDBe 2E8J · UniProt Q9NP97

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