MolNFT v1 · #35278 · protein

Structure of mouse wrn exonuclease domain

2E6L · Werner syndrome ATP-dependent helicase homolog: “Structure of mouse wrn exonuclease domain”. X-ray diffraction, 2 ligands (ZN, SO4), 1 pocket (best druggability 0.46). MolNFT v1 #35278 on GenesisL1: 3D structure, binding sites and…

PDB: 2E6L
Type: protein
Length: 186 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Werner syndrome ATP-dependent helicase homolog
EC: 3.6.1.-
UniProt: O09053
Ligands: ZN, SO4
Pockets: 1 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-)	protein	186	43% helix, 18% strand	O09053

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	158	0.46	0.76	23	SO4, ZN

Compared structures

2E6L · structure of mouse WRN exonuclease domain · the same entry in another collection · chain A against A, TM-score 1.00
O09053 · AlphaFold monomer V2.0 prediction for werner syndrome ATP-dependent helicase homolog… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O09053
Elsewhere: RCSB PDB 2E6L · PDBe 2E6L · UniProt O09053

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