MolNFT v1 · #500319 · protein
AlphaFold monomer V2.0 prediction for werner syndrome ATP-dependent helicase homolog (O09053)
O09053: “AlphaFold monomer V2.0 prediction for werner syndrome ATP-dependent helicase homolog (O09053)”. 13 pockets (best druggability 0.80). MolNFT v1 #500319 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O09053
- Type
- protein
- Length
- 1,401 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xb6928af8E36537c086d9ECbC974228d895800fDA
- Molecule
- Werner syndrome ATP-dependent helicase homolog
- UniProt
- O09053
- Pockets
- 13 · best druggability 0.80
Structure
1 distinct chain · 37% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Werner syndrome ATP-dependent helicase homolog | protein | 1401 | 37% helix, 9% strand | O09053 |
Pockets
13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 329 | 0.80 | 0.91 | 50 | empty |
| 2 | 578 | 0.80 | 0.86 | 51 | empty |
| 3 | 641 | 0.67 | 0.76 | 67 | empty |
| 4 | 481 | 0.62 | 0.76 | 45 | empty |
| 5 | 247 | 0.60 | 0.80 | 38 | empty |
Compared structures
- 2E6M · structure of mouse werner exonuclease domain · an experimental structure of the same protein · chain A against A, TM-score 0.13
- 2E6M · Structure of mouse werner exonuclease domain · an experimental structure of the same protein · chain A against A, TM-score 0.13
- 2E6L · structure of mouse WRN exonuclease domain · an experimental structure of the same protein · chain A against A, TM-score 0.13
- 2E6L · Structure of mouse wrn exonuclease domain · an experimental structure of the same protein · chain A against A, TM-score 0.13
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O09053
- Elsewhere: UniProt O09053 · AlphaFold DB O09053
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