MolNFT v1 · #35244 · protein

Solution structure of the ELL_N2 domain of target of RNA polymerase II elongation factor ELL2

2E5N: “Solution structure of the ELL_N2 domain of target of RNA polymerase II elongation factor ELL2”. Solution nmr, 1 pocket (best druggability 0.41). MolNFT v1 #35244 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2E5N
Type: protein
Length: 100 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA polymerase II elongation factor ELL2
UniProt: O00472
Pockets: 1 · best druggability 0.41

Structure

solution nmr · 1 distinct chain · 52% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA polymerase II elongation factor ELL2	protein	100	52% helix, 9% strand	O00472

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	69	0.41	0.80	15	empty

Compared structures

2E5N · Solution structure of the ELL_N2 domain of target of RNA polymerase II elongation factor… · the same entry in another collection · chain A against A, TM-score 1.00
O00472 · AlphaFold monomer V2.0 prediction for RNA polymerase II elongation factor ELL2 (O00472) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O00472
Elsewhere: RCSB PDB 2E5N · PDBe 2E5N · UniProt O00472

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