MolNFT v1 · #35160 · protein
Structural basis for selection of glycosylated substrate by SCFFBS1 ubiquitin ligase
2E32 · F-box only protein 2: “Structural basis for selection of glycosylated substrate by SCFFBS1 ubiquitin ligase”. X-ray diffraction, 7 pockets (best druggability 0.60). MolNFT v1 #35160 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2E32
- Type
- protein
- Length
- 740 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F-box only protein 2; S-phase kinase-associated protein 1A
- UniProt
- Q80UW2, P63208
- Pockets
- 7 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | F-box only protein 2 | protein | 240 | 21% helix, 35% strand | Q80UW2 |
| B, D | S-phase kinase-associated protein 1A | protein | 130 | 48% helix, 8% strand | P63208 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.60 | 0.89 | 19 | empty |
| 2 | 160 | 0.48 | 0.77 | 22 | empty |
| 3 | 152 | 0.46 | 0.76 | 29 | empty |
| 4 | 111 | 0.44 | 0.78 | 28 | empty |
| 5 | 111 | 0.41 | 0.76 | 22 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1439 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 1421 Ų buried · 9 hydrogen bonds · protein-protein
- B–D · 315 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 132 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2E32 · Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase · the same entry in another collection · chain A against A, TM-score 1.00
- Q80UW2 · AlphaFold monomer V2.0 prediction for F-box only protein 2 (Q80UW2) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P63208 · AlphaFold monomer V2.0 prediction for S-phase kinase-associated protein 1 (P63208) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q80UW2
- Every structure of UniProt P63208
- Elsewhere: RCSB PDB 2E32 · PDBe 2E32 · UniProt Q80UW2 · UniProt P63208
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