MolNFT v1 · #35021 · protein
The crystal structure of human P40(PHOX)
2DYB · Neutrophil cytosol factor 4: “The crystal structure of human P40(PHOX)”. X-ray diffraction, 13 pockets (best druggability 0.69). MolNFT v1 #35021 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2DYB
- Type
- protein
- Length
- 571 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neutrophil cytosol factor 4
- UniProt
- Q15080
- Pockets
- 13 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neutrophil cytosol factor 4 | protein | 298 | 31% helix, 32% strand | Q15080 |
| B | Neutrophil cytosol factor 4 | protein | 273 | 27% helix, 30% strand | Q15080 |
Pockets
13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 50 | 0.69 | 0.98 | 18 | empty |
| 2 | 281 | 0.61 | 0.79 | 30 | empty |
| 3 | 55 | 0.57 | 0.90 | 20 | empty |
| 4 | 246 | 0.56 | 0.78 | 29 | empty |
| 5 | 132 | 0.55 | 0.82 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 899 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (nonstandard).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15080
- Elsewhere: RCSB PDB 2DYB · PDBe 2DYB · UniProt Q15080
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