MolNFT v1 · #34944 · protein
Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome
2DVW · 26S proteasome non-ATPase regulatory subunit 10: “Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome”. X-ray diffraction, 2 pockets (best druggability 0.49). MolNFT v1 #34944 on GenesisL1: 3D…
- PDB
- 2DVW
- Type
- protein
- Length
- 302 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 26S proteasome non-ATPase regulatory subunit 10; 26S protease regulatory subunit 6B
- UniProt
- Q9Z2X2, P43686
- Pockets
- 2 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 56% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 26S proteasome non-ATPase regulatory subunit 10 | protein | 229 | 55% helix, 0% strand | Q9Z2X2 |
| B | 26S protease regulatory subunit 6B | protein | 73 | 59% helix, 3% strand | P43686 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 145 | 0.49 | 0.78 | 21 | empty |
| 2 | 68 | 0.27 | 0.72 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1257 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 2DVW · Structure of the Oncoprotein Gankyrin in Complex with S6 ATPase of the 26S Proteasome · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Z2X2 · AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 10… · a predicted model of the same protein · chain A against A, TM-score 0.99
- P43686 · AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit 6B (P43686) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Z2X2
- Every structure of UniProt P43686
- Elsewhere: RCSB PDB 2DVW · PDBe 2DVW · UniProt Q9Z2X2 · UniProt P43686
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