Research workbench
Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome
Analyse Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2DVW
- Type
- protein
- Length
- 302 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 26S proteasome non-ATPase regulatory subunit 10; 26S protease regulatory subunit 6B
- UniProt
- Q9Z2X2, P43686
- Pockets
- 2 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 56% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 26S proteasome non-ATPase regulatory subunit 10 | protein | 229 | 55% helix, 0% strand | Q9Z2X2 |
| B | 26S protease regulatory subunit 6B | protein | 73 | 59% helix, 3% strand | P43686 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 145 | 0.49 | 0.78 | 21 | empty |
| 2 | 68 | 0.27 | 0.72 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1257 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 2DVW · Structure of the Oncoprotein Gankyrin in Complex with S6 ATPase of the 26S Proteasome · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Z2X2 · AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 10… · a predicted model of the same protein · chain A against A, TM-score 0.99
- P43686 · AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit 6B (P43686) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Z2X2
- Every structure of UniProt P43686
- Elsewhere: RCSB PDB 2DVW · PDBe 2DVW · UniProt Q9Z2X2 · UniProt P43686
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