MolNFT v1 · #34794 · protein + RNA
Complex structure of cca-adding enzyme with trnaminidc and CTP
2DR8 · TRNA (33-mer): “Complex structure of cca-adding enzyme with trnaminidc and CTP”. X-ray diffraction, 3 ligands (CTP, MG, SO4), 5 pockets (best druggability 0.76). MolNFT v1 #34794 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 2DR8
- Type
- protein + RNA
- Length
- 470 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRNA (33-mer); Cca-adding enzyme
- EC
- 2.7.7.25, 2.7.7.21
- UniProt
- O28126
- Ligands
- CTP, MG, SO4
- Pockets
- 5 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | TRNA (33-mer) | rna | 33 | — | — |
| A | Cca-adding enzyme (EC 2.7.7.25, 2.7.7.21) | protein | 437 | 44% helix, 22% strand | O28126 |
Ligands and binding sites
- CTP · Cytidine-5'-triphosphate · ligand · chains B, A
- MG · Magnesium ion · metal · chains A
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 706 | 0.76 | 0.81 | 59 | MG, CTP |
| 2 | 648 | 0.62 | 0.73 | 58 | empty |
| 3 | 538 | 0.59 | 0.74 | 34 | SO4 |
| 4 | 390 | 0.55 | 0.74 | 27 | empty |
| 5 | 53 | 0.27 | 0.74 | 12 | empty |
Interfaces
1 interface between chains.
- B–A · 1341 Ų buried · 23 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O28126
- Elsewhere: RCSB PDB 2DR8 · PDBe 2DR8 · UniProt O28126
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