MolNFT v1 · #34416 · protein

Crystal structure of tk-RNase HII(1-200)-C

2DFE · Ribonuclease hii: “Crystal structure of tk-RNase HII(1-200)-C”. X-ray diffraction, 2 pockets (best druggability 0.35). MolNFT v1 #34416 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2DFE
Type: protein
Length: 209 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribonuclease hii
EC: 3.1.26.4
UniProt: O74035
Pockets: 2 · best druggability 0.35

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ribonuclease hii (EC 3.1.26.4)	protein	209	44% helix, 17% strand	O74035

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	63	0.35	0.77	15	empty
2	84	0.35	0.76	24	empty

Compared structures

2DFE · Crystal structure of Tk-RNase HII(1-200)-C · the same entry in another collection · chain A against A, TM-score 1.00
O74035 · AlphaFold monomer V2.0 prediction for ribonuclease hii (O74035) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O74035
Elsewhere: RCSB PDB 2DFE · PDBe 2DFE · UniProt O74035

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