MolNFT v1 · #3439 · protein

Crystal structure of procathepsin L

1CS8 · Human procathepsin L: “Crystal structure of procathepsin L”. X-ray diffraction, 1 pocket (best druggability 0.28). MolNFT v1 #3439 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1CS8
Type: protein
Length: 316 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Human procathepsin L
EC: 3.4.22.15
UniProt: P07711
Pockets: 1 · best druggability 0.28

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Human procathepsin L (EC 3.4.22.15)	protein	316	35% helix, 19% strand	P07711

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	52	0.28	0.75	17	empty

Modifications

Observed in the structure: 3 disulfide, 1 modified (disulfide, oxidation).

Compared structures

1CS8 · Crystal structure of procathepsin L · the same entry in another collection · chain A against A, TM-score 1.00
P07711 · AlphaFold monomer V2.0 prediction for procathepsin L (P07711) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07711
Elsewhere: RCSB PDB 1CS8 · PDBe 1CS8 · UniProt P07711

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