MolNFT v1 · #34145 · protein

Crystal structure analysis of susb

2D73 · Alpha-glucosidase susb: “Crystal structure analysis of susb”. X-ray diffraction, 1 ligand (CA), 10 pockets (best druggability 0.85). MolNFT v1 #34145 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2D73
Type: protein
Length: 1,434 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-glucosidase susb
EC: 3.2.1.20
Ligands: CA
Pockets: 10 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 19% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Alpha-glucosidase susb (EC 3.2.1.20)	protein	717	19% helix, 34% strand	—

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

10 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	911	0.85	0.86	131	empty
2	939	0.81	0.83	124	empty
3	167	0.79	0.95	34	empty
4	98	0.79	0.99	32	empty
5	165	0.78	0.94	33	empty

Interfaces

1 interface between chains.

A–B · 2250 Å² buried · 31 hydrogen bonds · protein-protein

Compared structures

2D73 · Crystal Structure Analysis of SusB · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2D73 · PDBe 2D73

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