MolNFT v1 · #33567 · protein

Solution structure of brct domain of POLY(ADP-ribose) polymerase-1

2COK · Poly [ADP-ribose] polymerase-1: “Solution structure of brct domain of POLY(ADP-ribose) polymerase-1”. Solution nmr, 1 pocket (best druggability 0.47). MolNFT v1 #33567 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2COK
Type: protein
Length: 113 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Poly [ADP-ribose] polymerase-1
EC: 2.4.2.30
UniProt: P09874
Pockets: 1 · best druggability 0.47

Structure

solution nmr · 1 distinct chain · 34% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Poly [ADP-ribose] polymerase-1 (EC 2.4.2.30)	protein	113	34% helix, 12% strand	P09874

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	185	0.47	0.75	27	empty

Compared structures

2COK · Solution structure of BRCT domain of poly(ADP-ribose) polymerase-1 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09874
Elsewhere: RCSB PDB 2COK · PDBe 2COK · UniProt P09874

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