MolNFT v1 · #33476 · protein
The crystal structure of the human RND1 GTPase in the active GTP bound state
2CLS · Rho-related GTP-binding protein RHO6: “The crystal structure of the human RND1 GTPase in the active GTP bound state”. X-ray diffraction, 2 ligands (GTP, MG), 2 pockets (best druggability 0.60). MolNFT v1 #33476 on GenesisL1: 3D…
- PDB
- 2CLS
- Type
- protein
- Length
- 357 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rho-related GTP-binding protein RHO6
- UniProt
- Q92730
- Ligands
- GTP, MG
- Pockets
- 2 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rho-related GTP-binding protein RHO6 | protein | 179 | 38% helix, 25% strand | Q92730 |
| B | Rho-related GTP-binding protein RHO6 | protein | 178 | 40% helix, 25% strand | Q92730 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 201 | 0.60 | 0.82 | 37 | GTP, MG |
| 2 | 175 | 0.57 | 0.81 | 36 | GTP, MG |
Interfaces
1 interface between chains.
- A–B · 556 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2CLS · The crystal structure of the human RND1 GTPase in the active GTP bound state · the same entry in another collection · chain B against B, TM-score 1.00
- Q92730 · AlphaFold monomer V2.0 prediction for rho-related GTP-binding protein RHO6 (Q92730) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92730
- Elsewhere: RCSB PDB 2CLS · PDBe 2CLS · UniProt Q92730
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.