Human NCK2 SH2-domain in complex with a decaphosphopeptide from translocated intimin receptor (tir) of epec

Structure

x-ray diffraction · 2 distinct chains · 20% helix, 31% strand (DSSP).

Ligands and binding sites

• ACE · Acetyl group · ligand · chains L
• MPD · (4S)-2-methyl-2,4-pentanediol · additive · chains A
• IPA · Isopropyl alcohol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–L · 585 Ų buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent, 1 modified (covalent ligand, phosphorylation).

Compared structures

• 2CIA · human nck2 sh2-domain in complex with a decaphosphopeptide from translocated intimin… · the same entry in another collection · chain A against A, TM-score 1.00
• O43639 · AlphaFold monomer V2.0 prediction for cytoplasmic protein NCK2 (O43639) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O43639
• Every structure of UniProt O50190
• Elsewhere: RCSB PDB 2CIA · PDBe 2CIA · UniProt O43639 · UniProt O50190