UniProt O43639
Cytoplasmic protein NCK2 (O43639)
Cytoplasmic protein NCK2 (UniProt O43639): 18 experimental structures and 1 predicted model on GenesisL1, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O43639
- Protein
- Cytoplasmic protein NCK2
- Experimental structures
- 18
- Predicted models
- 1
- Pockets
- 5 · 1 record with a druggable one
Structures
19 records of O43639 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1U5S | NMR structure of the complex between Nck-2 SH3 domain and PINCH-1 LIM4 domain | solution nmr | A | — | — |
| 1U5S | NMR structure of the complex between nck-2 SH3 domain and pinch-1 LIM4 domain | solution nmr | A | — | — |
| 1WX6 | Solution structure of the SH3 domain of the human cytoplasmic protein NCK2 | solution nmr | A | — | — |
| 1WX6 | Solution structure of the SH3 domain of the human cytoplasmic protein NCK2 | solution nmr | A | — | — |
| 1Z3K | Structural Insight into the Binding Diversity between the Tyr-Phosphorylated Human EphrinBs and… | solution nmr | A | — | — |
| 1Z3K | Structural insight into the binding diversity between the tyr- phosphorylated human ephrinbs and… | solution nmr | A | — | — |
| 2B86 | Solution structure of the first Src homology 3 domain of Nck2 | solution nmr | A | — | — |
| 2B86 | Solution structure of the first src homology 3 domain of NCK2 | solution nmr | A | — | — |
| 2CIA | human nck2 sh2-domain in complex with a decaphosphopeptide from translocated intimin receptor (tir)… | x-ray diffraction | A | — | — |
| 2CIA | Human NCK2 SH2-domain in complex with a decaphosphopeptide from translocated intimin receptor (tir)… | x-ray diffraction | A | — | — |
| 2FRW | Solution structure of the second SH3 domain of human adaptor protein NCK2 | solution nmr | A | — | — |
| 2FRW | Solution structure of the second SH3 domain of human adaptor protein NCK2 | solution nmr | A | — | — |
| 2FRY | Solution structure of the third SH3 domain of human NCK2 adaptor protein | solution nmr | A | — | — |
| 2FRY | Solution structure of the third SH3 domain of human NCK2 adaptor protein | solution nmr | A | — | — |
| 2JXB | Structure of CD3epsilon-Nck2 first SH3 domain complex | solution nmr | A | — | — |
| 2JXB | Structure of CD3EPSILON-NCK2 first SH3 domain complex | solution nmr | A | — | — |
| 4E6R | Crystal structure of a Cytoplasmic protein NCK2 (NCK2) from Homo sapiens at 2.20 A resolution | x-ray diffraction | A, B | — | — |
| 4E6R | Crystal structure of a cytoplasmic protein NCK2 (NCK2) from homo sapiens at 2.20 a resolution | x-ray diffraction | A, B | — | — |
| O43639 | AlphaFold monomer V2.0 prediction for cytoplasmic protein NCK2 (O43639) | predicted | A | — | 5 (best 0.50) |
Experiment against prediction
- 2CIA chain A against the predicted model O43639: TM-score 0.98, RMSD 0.48 Å
- 2CIA chain A against the predicted model O43639: TM-score 0.98, RMSD 0.48 Å
- 4E6R chain A against the predicted model O43639: TM-score 0.88, RMSD 1.21 Å
- 4E6R chain A against the predicted model O43639: TM-score 0.88, RMSD 1.21 Å
- 2B86 chain A against the predicted model O43639: TM-score 0.77, RMSD 2.00 Å
- 2B86 chain A against the predicted model O43639: TM-score 0.77, RMSD 2.00 Å
- 1U5S chain A against the predicted model O43639: TM-score 0.76, RMSD 2.33 Å
- 1U5S chain A against the predicted model O43639: TM-score 0.76, RMSD 2.33 Å
- 1WX6 chain A against the predicted model O43639: TM-score 0.70, RMSD 1.81 Å
- 1WX6 chain A against the predicted model O43639: TM-score 0.70, RMSD 1.81 Å
Elsewhere
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