MolNFT v1 · #33284 · protein

Crystal structure of human protein tyrosine phosphatase receptor type J

2CFV: “Crystal structure of human protein tyrosine phosphatase receptor type J”. X-ray diffraction, 2 ligands (NI, CL), 2 pockets (best druggability 0.34). MolNFT v1 #33284 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2CFV
Type: protein
Length: 268 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Human protein tyrosine phosphatase receptor type J
EC: 3.1.3.48
UniProt: Q12913
Ligands: NI, CL
Pockets: 2 · best druggability 0.34

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Human protein tyrosine phosphatase receptor type J (EC 3.1.3.48)	protein	268	42% helix, 19% strand	Q12913

Ligands and binding sites

NI · Nickel (II) ion · metal · 4 copies · chains A
CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	62	0.34	0.76	11	empty
2	58	0.28	0.73	14	empty

Compared structures

2CFV · Crystal structure of human protein tyrosine phosphatase receptor type J · the same entry in another collection · chain A against A, TM-score 1.00
Q12913 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase eta… · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12913
Elsewhere: RCSB PDB 2CFV · PDBe 2CFV · UniProt Q12913

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