MolNFT v1 · #33277 · protein
Non-discriminating glutamyl-tRNA synthetase from thermosynechococcus elongatus in complex with glu
2CFO: “Non-discriminating glutamyl-tRNA synthetase from thermosynechococcus elongatus in complex with glu”. X-ray diffraction, 1 ligand (GLU), 7 pockets (best druggability 0.70). MolNFT v1 #33277 on GenesisL1: 3D structure, binding sites…
- PDB
- 2CFO
- Type
- protein
- Length
- 971 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamyl-tRNA synthetase
- EC
- 6.1.1.17
- UniProt
- Q8DLI5
- Ligands
- GLU
- Pockets
- 7 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamyl-tRNA synthetase (EC 6.1.1.17) | protein | 484 | 51% helix, 12% strand | Q8DLI5 |
| B | Glutamyl-tRNA synthetase (EC 6.1.1.17) | protein | 487 | 50% helix, 12% strand | Q8DLI5 |
Ligands and binding sites
- GLU · Glutamic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 590 | 0.70 | 0.79 | 50 | GLU |
| 2 | 460 | 0.69 | 0.80 | 46 | empty |
| 3 | 333 | 0.57 | 0.76 | 47 | empty |
| 4 | 171 | 0.40 | 0.72 | 28 | empty |
| 5 | 62 | 0.35 | 0.78 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 823 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2CFO · Non-Discriminating Glutamyl-tRNA Synthetase from Thermosynechococcus elongatus in Complex… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8DLI5 · AlphaFold monomer V2.0 prediction for glutamate--tRNA ligase (Q8DLI5) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8DLI5
- Elsewhere: RCSB PDB 2CFO · PDBe 2CFO · UniProt Q8DLI5
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.