MolNFT v1 · #33145 · protein

Structure of native and apo carbonic anhydrase II and some of its anion-ligand complexes

2CBE: “Structure of native and apo carbonic anhydrase II and some of its anion-ligand complexes”. X-ray diffraction, 2 pockets (best druggability 0.51). MolNFT v1 #33145 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2CBE
Type: protein
Length: 258 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Carbonic anhydrase II
EC: 4.2.1.1
UniProt: P00918
Pockets: 2 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 16% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Carbonic anhydrase II (EC 4.2.1.1)	protein	258	16% helix, 31% strand	P00918

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	104	0.51	0.82	23	empty
2	55	0.28	0.74	14	empty

Compared structures

2CBE · Structure of native and apo carbonic anhydrase II and some of its anion-ligand complexes · the same entry in another collection · chain A against A, TM-score 1.00
P00918 · AlphaFold monomer V2.0 prediction for carbonic anhydrase 2 (P00918) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00918
Elsewhere: RCSB PDB 2CBE · PDBe 2CBE · UniProt P00918

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