MolNFT v1 · #33099 · protein
Atomic resolution structure of cu-zn human superoxide dismutase
2C9V · Superoxide dismutase [cu-zn]: “Atomic resolution structure of cu-zn human superoxide dismutase”. X-ray diffraction, 4 ligands (CU, ZN, NA), 2 pockets (best druggability 0.64). MolNFT v1 #33099 on GenesisL1: 3D structure, binding…
- PDB
- 2C9V
- Type
- protein
- Length
- 306 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Superoxide dismutase [cu-zn]
- EC
- 1.15.1.1
- UniProt
- P00441
- Ligands
- CU, ZN, NA, SO4
- Pockets
- 2 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 8% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, F | Superoxide dismutase [cu-zn] (EC 1.15.1.1) | protein | 153 | 8% helix, 41% strand | P00441 |
Ligands and binding sites
- CU · Copper (II) ion · metal · 2 copies · chains A, F
- ZN · Zinc ion · metal · 2 copies · chains A, F
- NA · Sodium ion · metal · 2 copies · chains A, F
- SO4 · Sulfate ion · ion · 5 copies · chains A, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 182 | 0.64 | 0.85 | 29 | empty |
| 2 | 97 | 0.32 | 0.73 | 19 | empty |
Interfaces
1 interface between chains.
- A–F · 725 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 2C9V · Atomic resolution structure of Cu-Zn Human Superoxide dismutase · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00441
- Elsewhere: RCSB PDB 2C9V · PDBe 2C9V · UniProt P00441
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.