MolNFT v1 · #33050 · protein
Complex of echovirus type 12 with domains 1, 2, 3 and 4 of its receptor decay accelerating factor (CD55) by cryo electron microscopy at 16 a
2C8I · Echovirus 11 coat protein VP1: “Complex of echovirus type 12 with domains 1, 2, 3 and 4 of its receptor decay accelerating factor (CD55) by…”. Electron microscopy, 1 pocket (best druggability 0.37). MolNFT v1 #33050 on GenesisL1: 3D…
- PDB
- 2C8I
- Type
- protein
- Length
- 1,091 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Echovirus 11 coat protein VP1; Echovirus 11 coat protein VP2; Echovirus 11 coat protein…
- UniProt
- P29813, P08174
- Pockets
- 1 · best druggability 0.37
Structure
electron microscopy · 5 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Echovirus 11 coat protein VP1 | protein | 289 | 0% helix, 0% strand | P29813 |
| B | Echovirus 11 coat protein VP2 | protein | 252 | 0% helix, 0% strand | P29813 |
| C | Echovirus 11 coat protein VP3 | protein | 238 | 0% helix, 0% strand | P29813 |
| D | Echovirus 11 coat protein VP4 | protein | 60 | 0% helix, 0% strand | P29813 |
| E | Complement decay-accelerating factor | protein | 252 | 0% helix, 0% strand | P08174 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 99 | 0.37 | 0.73 | 29 | empty |
Interfaces
8 interfaces between chains.
- A–C · 631 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 340 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 242 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 210 Ų buried · 0 hydrogen bonds · protein-protein
- B–E · 137 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2C8I · Complex Of Echovirus Type 12 With Domains 1, 2, 3 and 4 Of Its Receptor Decay… · the same entry in another collection · chain A against A, TM-score 1.00
- P08174 · AlphaFold monomer V2.0 prediction for complement decay-accelerating factor (P08174) · a predicted model of the same protein · chain E against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29813
- Every structure of UniProt P08174
- Elsewhere: RCSB PDB 2C8I · PDBe 2C8I · UniProt P29813 · UniProt P08174
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