MolNFT v1 · #32821 · protein
Structure of the KAP60P:NUP2 complex
2C1T · Importin alpha subunit: “Structure of the KAP60P:NUP2 complex”. X-ray diffraction, 8 pockets (best druggability 0.81). MolNFT v1 #32821 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2C1T
- Type
- protein
- Length
- 921 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin alpha subunit; Nucleoporin NUP2
- UniProt
- Q02821, P32499
- Pockets
- 8 · best druggability 0.81
Structure
x-ray diffraction · 3 distinct chains · 65% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Importin alpha subunit | protein | 423 | 74% helix, 0% strand | Q02821 |
| C | Nucleoporin NUP2 | protein | 36 | 11% helix, 3% strand | P32499 |
| D | Nucleoporin NUP2 | protein | 39 | 10% helix, 5% strand | P32499 |
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1163 | 0.81 | 0.82 | 96 | empty |
| 2 | 95 | 0.39 | 0.76 | 18 | empty |
| 3 | 83 | 0.38 | 0.77 | 17 | empty |
| 4 | 103 | 0.38 | 0.75 | 20 | empty |
| 5 | 97 | 0.37 | 0.76 | 17 | empty |
Interfaces
5 interfaces between chains.
- B–D · 1788 Ų buried · 36 hydrogen bonds · protein-protein
- A–C · 1767 Ų buried · 37 hydrogen bonds · protein-protein
- A–B · 1060 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 174 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 166 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2C1T · Structure of the Kap60p:Nup2 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q02821 · AlphaFold monomer V2.0 prediction for importin subunit alpha (Q02821) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P32499 · AlphaFold monomer V2.0 prediction for nucleoporin NUP2 (P32499) · a predicted model of the same protein · chain D against A, TM-score 0.33
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02821
- Every structure of UniProt P32499
- Elsewhere: RCSB PDB 2C1T · PDBe 2C1T · UniProt Q02821 · UniProt P32499
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