MolNFT v1 · #32757 · protein
The crystal structure of BCL-xl in complex with full-length bad
2BZW · Apoptosis regulator BCL-X: “The crystal structure of BCL-xl in complex with full-length bad”. X-ray diffraction, 1 pocket (best druggability 0.35). MolNFT v1 #32757 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2BZW
- Type
- protein
- Length
- 171 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apoptosis regulator BCL-X; BCL2-antagonist of cell death
- UniProt
- Q64373, Q61337
- Pockets
- 1 · best druggability 0.35
Structure
x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Apoptosis regulator BCL-X | protein | 144 | 74% helix, 0% strand | Q64373 |
| B | BCL2-antagonist of cell death | protein | 27 | 81% helix, 0% strand | Q61337 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 78 | 0.35 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1148 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 2BZW · The crystal structure of BCL-XL in complex with full-length BAD · the same entry in another collection · chain A against A, TM-score 1.00
- Q64373 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 1 (Q64373) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q61337 · AlphaFold monomer V2.0 prediction for BCL2-associated agonist of cell death (Q61337) · a predicted model of the same protein · chain B against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q64373
- Every structure of UniProt Q61337
- Elsewhere: RCSB PDB 2BZW · PDBe 2BZW · UniProt Q64373 · UniProt Q61337
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