MolNFT v1 · #32743 · protein + DNA
Structural basis for DNA bridging by barrier-to- autointegration factor (baf)
2BZF · Barrier-to-autointegration factor: “Structural basis for DNA bridging by barrier-to- autointegration factor (baf)”. X-ray diffraction, 1 pocket (best druggability 0.44). MolNFT v1 #32743 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2BZF
- Type
- protein + DNA
- Length
- 102 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Barrier-to-autointegration factor; 5'-D(*GP*TP*GP*GP*AP*GP*GP)-3'…
- UniProt
- O75531
- Pockets
- 1 · best druggability 0.44
Structure
x-ray diffraction · 3 distinct chains · 67% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Barrier-to-autointegration factor | protein | 88 | 67% helix, 0% strand | O75531 |
| B | 5'-D(*GP*TP*GP*GP*AP*GP*GP)-3' | dna | 7 | — | — |
| C | 5'-D(*CP*CP*TP*CP*CP*AP*CP)-3' | dna | 7 | — | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 97 | 0.44 | 0.79 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–C · 334 Ų buried · 11 hydrogen bonds · protein-nucleic
- B–C · 316 Ų buried · 29 hydrogen bonds · nucleic-nucleic
- A–B · 142 Ų buried · 2 hydrogen bonds · protein-nucleic
Compared structures
- 2BZF · Structural basis for DNA bridging by barrier-to-autointegration factor (BAF) · the same entry in another collection · chain A against A, TM-score 1.00
- O75531 · AlphaFold monomer V2.0 prediction for barrier-to-autointegration factor (O75531) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75531
- Elsewhere: RCSB PDB 2BZF · PDBe 2BZF · UniProt O75531
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