MolNFT v1 · #32595 · protein
Crystal structure of the human protein tyrosine phosphatase PTPN5 at 1.8A resolution
2BV5 · Tyrosine-protein phosphatase, non-receptor type 5: “Crystal structure of the human protein tyrosine phosphatase PTPN5 at 1.8A resolution”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.47). MolNFT v1 #32595 on…
- PDB
- 2BV5
- Type
- protein
- Length
- 282 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase, non-receptor type 5
- EC
- 3.1.3.48
- UniProt
- P54829
- Ligands
- SO4
- Pockets
- 1 · best druggability 0.47
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase, non-receptor type 5 (EC 3.1.3.48) | protein | 282 | 40% helix, 21% strand | P54829 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 124 | 0.47 | 0.79 | 22 | empty |
Modifications
Observed in the structure: 1 modified (acetylation).
Compared structures
- 2BV5 · Crystal structure of the human protein tyrosine phosphatase PTPN5 at 1.8A resolution · the same entry in another collection · chain A against A, TM-score 1.00
- P54829 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 5… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54829
- Elsewhere: RCSB PDB 2BV5 · PDBe 2BV5 · UniProt P54829
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