UniProt P54829
Tyrosine-protein phosphatase non-receptor type 5 (P54829)
Tyrosine-protein phosphatase non-receptor type 5 (UniProt P54829), EC 3.1.3.48: 13 experimental structures on GenesisL1, 6 ligands bound, 1 pocket. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P54829
- Protein
- Tyrosine-protein phosphatase non-receptor type 5
- EC
- 3.1.3.48
- Experimental structures
- 13
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 1 · 0 records with a druggable one
Structures
13 records of P54829 in the MolNFT archive: 13 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2BIJ | Crystal structure of the human protein tyrosine phosphatase PTPN5 (STEP, striatum enriched enriched… | x-ray diffraction | A | — | — |
| 2BIJ | Crystal structure of the human protein tyrosine phosphatase PTPN5 (step, striatum enriched enriched… | x-ray diffraction | A | — | — |
| 2BV5 | Crystal structure of the human protein tyrosine phosphatase PTPN5 at 1.8A resolution | x-ray diffraction | A | — | — |
| 2BV5 | Crystal structure of the human protein tyrosine phosphatase PTPN5 at 1.8A resolution | x-ray diffraction | A | — | — |
| 2CJZ | crystal structure of the c472s mutant of human protein tyrosine phosphatase ptpn5 (step, striatum… | x-ray diffraction | A | — | — |
| 2CJZ | Crystal structure of the C472S mutant of human protein tyrosine phosphatase PTPN5 (step, striatum… | x-ray diffraction | A | — | — |
| 5OVR | X-ray characterization of striatal-enriched protein tyrosine phosphatase inhibitors | x-ray diffraction | A | AXK | — |
| 5OVX | X-ray characterization of striatal-enriched protein tyrosine phosphatase inhibitors | x-ray diffraction | A | AY5 | — |
| 5OW1 | X-ray characterization of striatal-enriched protein tyrosine phosphatase inhibitors | x-ray diffraction | A | AY8 | — |
| 6H8R | Crystal structure of the human protein tyrosine phosphatase PTPN5 (step) in complex with compound 2 | x-ray diffraction | A | SO4, FWB | — |
| 6H8R | Crystal structure of the human protein tyrosine phosphatase PTPN5 (step) in complex with compound 2 | x-ray diffraction | A | SO4, FWB | — |
| 9EEZ | STEP (PTPN5) with active-site disulfide bond and covalent ligand bound to distal C505 and C518 | x-ray diffraction | A | A1BHT, SO4 | 1 (best 0.46) |
| P54829 | AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 5 (P54829) | — | — | — |
Ligands
- SO4 · Sulfate ion · in 3 records
- FWB · 3-[(2~{S})-2-azanylpropyl]-5-(trifluoromethyl)phenol · in 2 records
- A1BHT · [4-(bromoacetyl)phenoxy]acetic acid · in 1 record
- AXK · [(~{S})-[4-[3-[(~{R})-(3,4-dichlorophenyl)-oxidanyl-methyl]phenyl]phenyl]-oxidanyl-methyl]phosphonic acid · in 1 record
- AY5 · [(~{S})-[4-[3-[(~{S})-(3,4-dichlorophenyl)-oxidanyl-methyl]phenyl]phenyl]-oxidanyl-methyl]phosphonic acid · in 1 record
- AY8 · [[3-(3-cyclohexyl-2-oxidanyl-phenyl)phenyl]-bis(fluoranyl)methyl]phosphonic acid · in 1 record
Elsewhere
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