MolNFT v1 · #32520 · protein

Crystal structure of the plasmodium falciparum purine nucleoside phosphorylase complexed with inosine

2BSX: “Crystal structure of the plasmodium falciparum purine nucleoside phosphorylase complexed with inosine”. X-ray diffraction, 1 ligand (NOS), 1 pocket (best druggability 0.61). MolNFT v1 #32520 on GenesisL1: 3D structure, binding sites…

PDB: 2BSX
Type: protein
Length: 241 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Purine nucleoside phosphorylase
EC: 2.4.2.1
UniProt: Q8T9Z7
Ligands: NOS
Pockets: 1 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Purine nucleoside phosphorylase (EC 2.4.2.1)	protein	241	31% helix, 28% strand	Q8T9Z7

Ligands and binding sites

NOS · Inosine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	296	0.61	0.79	41	NOS

Compared structures

2BSX · Crystal structure of the Plasmodium falciparum purine nucleoside phosphorylase complexed… · the same entry in another collection · chain A against A, TM-score 1.00
Q8T9Z7 · AlphaFold monomer V2.0 prediction for purine nucleoside phosphorylase (Q8T9Z7) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8T9Z7
Elsewhere: RCSB PDB 2BSX · PDBe 2BSX · UniProt Q8T9Z7

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