UniProt Q8T9Z7
Purine nucleoside phosphorylase (Q8T9Z7)
Purine nucleoside phosphorylase (UniProt Q8T9Z7), EC 2.4.2.1: 12 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q8T9Z7
- Protein
- Purine nucleoside phosphorylase
- EC
- 2.4.2.1
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 9 · 4 records with a druggable one
Structures
13 records of Q8T9Z7 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2BSX | Crystal structure of the Plasmodium falciparum purine nucleoside phosphorylase complexed with… | x-ray diffraction | A | NOS | 1 (best 0.61) |
| 2BSX | Crystal structure of the plasmodium falciparum purine nucleoside phosphorylase complexed with… | x-ray diffraction | A | — | — |
| 3PHC | Crystal Structure of Plasmodium falciparum purine nucleoside phosphorylase in complex with… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3PHC | Crystal structure of plasmodium falciparum purine nucleoside phosphorylase in complex with… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5ZNC | Plasmodium falciparum purine nucleoside phosphorylase in complex with quinine | x-ray diffraction | A | QI9, PO4 | 1 (best 0.65) |
| 5ZNC | Plasmodium falciparum purine nucleoside phosphorylase in complex with quinine | x-ray diffraction | A | QI9, PO4 | — |
| 5ZNI | Plasmodium falciparum purine nucleoside phosphorylase in complex with mefloquine | x-ray diffraction | A | PO4, YMZ | 1 (best 0.49) |
| 5ZNI | Plasmodium falciparum purine nucleoside phosphorylase in complex with mefloquine | x-ray diffraction | A | PO4, YMZ | — |
| 6AQS | Crystal structure of Plasmodium falciparum purine nucleoside phosphorylase (V181D) mutant complexed… | x-ray diffraction | A | PO4, IM5 | 1 (best 0.46) |
| 6AQS | Crystal structure of plasmodium falciparum purine nucleoside phosphorylase (V181D) mutant complexed… | x-ray diffraction | A | PO4, IM5 | — |
| 6AQU | Crystal Structure of Plasmodium falciparum purine nucleoside phosphorylase: The M183L mutant | x-ray diffraction | A, B | PO4 | 4 (best 0.60) |
| 6AQU | Crystal structure of plasmodium falciparum purine nucleoside phosphorylase: the M183L mutant | x-ray diffraction | A, B | PO4 | — |
| Q8T9Z7 | AlphaFold monomer V2.0 prediction for purine nucleoside phosphorylase (Q8T9Z7) | predicted | A | — | 1 (best 0.62) |
Ligands
Experiment against prediction
- 6AQS chain A against the predicted model Q8T9Z7: TM-score 1.00, RMSD 0.23 Å
- 6AQS chain A against the predicted model Q8T9Z7: TM-score 1.00, RMSD 0.23 Å
- 3PHC chain A against the predicted model Q8T9Z7: TM-score 1.00, RMSD 0.24 Å
- 3PHC chain A against the predicted model Q8T9Z7: TM-score 1.00, RMSD 0.24 Å
- 5ZNI chain A against the predicted model Q8T9Z7: TM-score 1.00, RMSD 0.35 Å
- 5ZNI chain A against the predicted model Q8T9Z7: TM-score 1.00, RMSD 0.35 Å
- 5ZNC chain A against the predicted model Q8T9Z7: TM-score 0.99, RMSD 0.48 Å
- 5ZNC chain A against the predicted model Q8T9Z7: TM-score 0.99, RMSD 0.48 Å
- 6AQU chain A against the predicted model Q8T9Z7: TM-score 0.99, RMSD 0.62 Å
- 6AQU chain A against the predicted model Q8T9Z7: TM-score 0.99, RMSD 0.62 Å
Elsewhere
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