MolNFT v1 · #32394 · protein
Crystal structure of filamin a domain 17 and gpib alpha cytoplasmic domain complex
2BP3: “Crystal structure of filamin a domain 17 and gpib alpha cytoplasmic domain complex”. X-ray diffraction, 2 pockets (best druggability 0.33). MolNFT v1 #32394 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2BP3
- Type
- protein
- Length
- 209 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Filamin a; Platelet glycoprotein ib alpha chain
- UniProt
- P21333, P07359
- Pockets
- 2 · best druggability 0.33
Structure
x-ray diffraction · 4 distinct chains · 3% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Filamin a | protein | 91 | 3% helix, 56% strand | P21333 |
| B | Filamin a | protein | 90 | 3% helix, 57% strand | P21333 |
| S | Platelet glycoprotein ib alpha chain | protein | 11 | 0% helix, 82% strand | P07359 |
| T | Platelet glycoprotein ib alpha chain | protein | 17 | 0% helix, 53% strand | P07359 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains A, T, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 78 | 0.33 | 0.74 | 16 | empty |
| 2 | 56 | 0.33 | 0.77 | 13 | empty |
Interfaces
4 interfaces between chains.
- A–T · 772 Ų buried · 18 hydrogen bonds · protein-protein
- B–S · 705 Ų buried · 16 hydrogen bonds · protein-protein
- B–T · 525 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 108 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2BP3 · Crystal structure of Filamin A domain 17 and GPIb alpha cytoplasmic domain complex · the same entry in another collection · chain T against T, TM-score 1.00
- P21333 · AlphaFold monomer V2.0 prediction for filamin-a (P21333) · a predicted model of the same protein · chain B against A, TM-score 0.96
- P07359 · AlphaFold monomer V2.0 prediction for platelet glycoprotein ib alpha chain (P07359) · a predicted model of the same protein · chain S against A, TM-score 0.54
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21333
- Every structure of UniProt P07359
- Elsewhere: RCSB PDB 2BP3 · PDBe 2BP3 · UniProt P21333 · UniProt P07359
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