MolNFT v1 · #32353 · protein
Structural and kinetic basis for heightened immunogenicity of T cell vaccines
2BNU · T-cell receptor alpha chain C region: “Structural and kinetic basis for heightened immunogenicity of T cell vaccines”. X-ray diffraction, 4 pockets (best druggability 0.71). MolNFT v1 #32353 on GenesisL1: 3D structure, binding sites…
- PDB
- 2BNU
- Type
- protein
- Length
- 444 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T-cell receptor alpha chain C region; T-cell receptor beta chain C region
- UniProt
- P01848, P01850
- Pockets
- 4 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | T-cell receptor alpha chain C region | protein | 203 | 5% helix, 47% strand | P01848 |
| B | T-cell receptor beta chain C region | protein | 241 | 7% helix, 50% strand | P01848, P01850 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 980 | 0.71 | 0.75 | 76 | empty |
| 2 | 113 | 0.37 | 0.74 | 26 | empty |
| 3 | 56 | 0.29 | 0.75 | 17 | empty |
| 4 | 63 | 0.29 | 0.73 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 2441 Ų buried · 33 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 2BNU · Structural and kinetic basis for heightened immunogenicity of T cell vaccines · the same entry in another collection · chain A against A, TM-score 1.00
- P01850 · AlphaFold monomer V2.0 prediction for T cell receptor beta constant 1 (P01850) · a predicted model of the same protein · chain B against A, TM-score 0.53
- P01848 · AlphaFold monomer V2.0 prediction for T cell receptor alpha chain constant (P01848) · a predicted model of the same protein · chain A against A, TM-score 0.41
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01848
- Every structure of UniProt P01850
- Elsewhere: RCSB PDB 2BNU · PDBe 2BNU · UniProt P01848 · UniProt P01850
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