MolNFT v1 · #32214 · protein
Structure of recombinant human lactoferrin produced in the milk of transgenic cows
2BJJ · Lactotransferrin: “Structure of recombinant human lactoferrin produced in the milk of transgenic cows”. X-ray diffraction, 3 ligands (NAG, FE, CO3), 9 pockets (best druggability 0.77). MolNFT v1 #32214 on GenesisL1: 3D structure…
- PDB
- 2BJJ
- Type
- protein
- Length
- 692 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lactotransferrin
- UniProt
- P02788
- Ligands
- NAG, FE, CO3
- Pockets
- 9 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| X | Lactotransferrin | protein | 692 | 35% helix, 18% strand | P02788 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains X
- FE · Fe (III) ion · metal · 2 copies · chains X
- CO3 · Carbonate ion · ion · 2 copies · chains X
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 291 | 0.77 | 0.89 | 37 | empty |
| 2 | 241 | 0.74 | 0.89 | 39 | empty |
| 3 | 256 | 0.58 | 0.79 | 26 | empty |
| 4 | 189 | 0.54 | 0.79 | 31 | empty |
| 5 | 195 | 0.51 | 0.77 | 29 | empty |
Modifications
Observed in the structure: 16 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 2BJJ · Structure of recombinant human lactoferrin produced in the milk of transgenic cows · the same entry in another collection · chain X against X, TM-score 1.00
- P02788 · AlphaFold monomer V2.0 prediction for lactotransferrin (P02788) · a predicted model of the same protein · chain X against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02788
- Elsewhere: RCSB PDB 2BJJ · PDBe 2BJJ · UniProt P02788
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