Research workbench
Structure of recombinant human lactoferrin produced in the milk of transgenic cows
Analyse Structure of recombinant human lactoferrin produced in the milk of transgenic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2BJJ
- Type
- protein
- Length
- 692 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lactotransferrin
- UniProt
- P02788
- Ligands
- NAG, FE, CO3
- Pockets
- 9 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| X | Lactotransferrin | protein | 692 | 35% helix, 18% strand | P02788 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains X
- FE · Fe (III) ion · metal · 2 copies · chains X
- CO3 · Carbonate ion · ion · 2 copies · chains X
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 291 | 0.77 | 0.89 | 37 | empty |
| 2 | 241 | 0.74 | 0.89 | 39 | empty |
| 3 | 256 | 0.58 | 0.79 | 26 | empty |
| 4 | 189 | 0.54 | 0.79 | 31 | empty |
| 5 | 195 | 0.51 | 0.77 | 29 | empty |
Modifications
Observed in the structure: 16 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 2BJJ · Structure of recombinant human lactoferrin produced in the milk of transgenic cows · the same entry in another collection · chain X against X, TM-score 1.00
- P02788 · AlphaFold monomer V2.0 prediction for lactotransferrin (P02788) · a predicted model of the same protein · chain X against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02788
- Elsewhere: RCSB PDB 2BJJ · PDBe 2BJJ · UniProt P02788
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