MolNFT v1 · #32156 · protein
Structure of COMB10 of the com type IV secretion system of helicobacter pylori
2BHV: “Structure of COMB10 of the com type IV secretion system of helicobacter pylori”. X-ray diffraction, 12 pockets (best druggability 0.76). MolNFT v1 #32156 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2BHV
- Type
- protein
- Length
- 1,138 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- COMB10
- UniProt
- O24883
- Pockets
- 12 · best druggability 0.76
Structure
x-ray diffraction · 6 distinct chains · 20% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | COMB10 | protein | 191 | 21% helix, 35% strand | O24883 |
| B | COMB10 | protein | 192 | 19% helix, 37% strand | O24883 |
| C | COMB10 | protein | 188 | 21% helix, 36% strand | O24883 |
| D | COMB10 | protein | 189 | 21% helix, 39% strand | O24883 |
| E | COMB10 | protein | 190 | 17% helix, 39% strand | O24883 |
| F | COMB10 | protein | 188 | 20% helix, 37% strand | O24883 |
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 625 | 0.76 | 0.82 | 58 | empty |
| 2 | 1124 | 0.73 | 0.77 | 81 | empty |
| 3 | 364 | 0.72 | 0.84 | 39 | empty |
| 4 | 371 | 0.67 | 0.80 | 40 | empty |
| 5 | 326 | 0.56 | 0.75 | 32 | empty |
Interfaces
11 interfaces between chains.
- A–E · 1566 Ų buried · 26 hydrogen bonds · protein-protein
- D–F · 1556 Ų buried · 18 hydrogen bonds · protein-protein
- B–C · 1469 Ų buried · 21 hydrogen bonds · protein-protein
- B–D · 1083 Ų buried · 8 hydrogen bonds · protein-protein
- C–E · 488 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2BHV · Structure of ComB10 of the Com Type IV secretion system of Helicobacter pylori · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O24883
- Elsewhere: RCSB PDB 2BHV · PDBe 2BHV · UniProt O24883
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.