Research workbench
Structure of COMB10 of the com type IV secretion system of helicobacter pylori
Analyse Structure of COMB10 of the com type IV secretion system of helicobacter pylori in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2BHV
- Type
- protein
- Length
- 1,138 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- COMB10
- UniProt
- O24883
- Pockets
- 12 · best druggability 0.76
Structure
x-ray diffraction · 6 distinct chains · 20% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | COMB10 | protein | 191 | 21% helix, 35% strand | O24883 |
| B | COMB10 | protein | 192 | 19% helix, 37% strand | O24883 |
| C | COMB10 | protein | 188 | 21% helix, 36% strand | O24883 |
| D | COMB10 | protein | 189 | 21% helix, 39% strand | O24883 |
| E | COMB10 | protein | 190 | 17% helix, 39% strand | O24883 |
| F | COMB10 | protein | 188 | 20% helix, 37% strand | O24883 |
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 625 | 0.76 | 0.82 | 58 | empty |
| 2 | 1124 | 0.73 | 0.77 | 81 | empty |
| 3 | 364 | 0.72 | 0.84 | 39 | empty |
| 4 | 371 | 0.67 | 0.80 | 40 | empty |
| 5 | 326 | 0.56 | 0.75 | 32 | empty |
Interfaces
11 interfaces between chains.
- A–E · 1566 Ų buried · 26 hydrogen bonds · protein-protein
- D–F · 1556 Ų buried · 18 hydrogen bonds · protein-protein
- B–C · 1469 Ų buried · 21 hydrogen bonds · protein-protein
- B–D · 1083 Ų buried · 8 hydrogen bonds · protein-protein
- C–E · 488 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2BHV · Structure of ComB10 of the Com Type IV secretion system of Helicobacter pylori · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O24883
- Elsewhere: RCSB PDB 2BHV · PDBe 2BHV · UniProt O24883
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